Kitsada WudhikarnUdomsak BunworasateJakrawadee JulamaneeArnuparp LekhakulaSupachai EkwattanakitArchrob KhuhapinantSuporn ChuncharuneePimjai NiparuckTontanai NumbenjaponKannadit PrayongratanaNonglak KanitsapSomchai WongkhanteeNisa MakruasiPeerapon WongLalita NorasetthadaWeerasak NawarawongChittima SirijerachaiKanchana ChansungTawatchai SuwanbanPannee PraditsuktavornTanin IntragumtornchaiChulalongkorn UniversityNaresuan UniversityKhon Kaen UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityThammasat UniversityFaculty of Medicine, Siriraj Hospital, Mahidol UniversityPhramongkutklao College of MedicinePrince of Songkla UniversityRajavithi HospitalChiang Mai UniversitySrinakharinwirot UniversityKhonkaen Regional HospitalChulabhorn Hospital2020-01-272020-01-272020-01-01Journal of Geriatric Oncology. Vol.11, No.1 (2020), 62-68187940682-s2.0-85063582476https://repository.li.mahidol.ac.th/handle/123456789/49672© 2019 Introduction: Peripheral T cell NHL (PTCL) and natural killer/T cell NHL (NKTCL) are relatively rare disorders. Data on clinical presentation, treatment and outcome are limited especially in older age groups. Methods: We identified 127 patients with PTCL and NKTCL, excluding cutaneous T/NK cell lymphoma, aged over 60 years old from Thailand nationwide multicenter registry. Results: Of 127 patients, median age of diagnosis was 67 years old. Patients aged older than 75 years old had similar characteristics to younger (60–74 years old) but higher comorbidity index. Seventy-nine patients (62.2%) received intensive/definite multi-agent chemotherapy, however, the proportion was significant lower in older patients (70.4% vs 34.5%, p <. 001). After a median follow up duration of 17.3 months, 2-year progression free survival and overall survival were 38.1% and 48.5%. Univariate and multivariable analysis demonstrated older age, poor performance status and absence of definite multi-agent chemotherapy were associated with inferior survival. Definite multi-agent lymphoma specific chemotherapy was an independent factor for overall survival after adjustment for age, comorbidity index, performance status and prognostic index for T cell lymphoma. Conclusion: Despite overall poor prognosis of PTCL and NKTCL in older adults, chemotherapy could result in objective response and long-term survival in selected patients of this vulnerable age group thus emphasizing the importance of comprehensive geriatric evaluation.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.jgo.2019.03.016