Lalida TuntipumiamornSuphalerk LohasammakulPittaya DankulchaiPitchayut NakkrasaeMahidol UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2019-08-282019-08-282018-01-01Journal of Contemporary Brachytherapy. Vol.10, No.5 (2018), 418-4241689832X2-s2.0-85056625708https://repository.li.mahidol.ac.th/handle/123456789/47056© 2018 Termedia Publishing House Ltd.. All Rights Reserved. Purpose: The dose distributions obtained from three imaging approaches for target delineation in cervical cancer using high-dose-rate (HDR) brachytherapy were investigated. Material and methods: Ten cervical cancer patients receiving four fractions of HDR brachytherapy were enrolled. Based on different imaging approaches, three brachytherapy plans were developed for each patient: with the high-risk clinical target volume (HRCTV) delineated on magnetic resonance (MRI) images for every fraction (approach A; MRIonly); on MRI for the first fraction and computed tomography (CT) images for the subsequent fractions (approach B; MRI1st/CT); and on CT images for all fractions (approach C; CT-only). The volume, height, width at point A, width at maximum level, and dosimetric parameters (D100, D98, D95, and D90 of the HRCTV; and D0.1cc, D1cc, and D2cc of all organs at risk, or organ at risk-OAR: bladder, rectum, sigmoid colon, and bowel) provided by each approach were compared. Results: The mean HRCTV volume, width, and height obtained from approach C (CT-only) were overestimated compared to those from approaches A (MRI-only) and B (MRI1st/CT). The doses to the HRCTV for approaches A and B were similar. However, the HRCTV doses for approach C were significantly lower than those for approaches A and B for all parameters (D95-D100). As to the OAR, the three approaches showed no differences. Conclusions: A combination of MRI and CT is a safe alternative approach for cervical cancer HDR brachytherapy. The technique provides comparable dosimetric outcomes to MRI-based planning, while being more cost-effective.Mahidol UniversityMedicineArticleSCOPUS10.5114/jcb.2018.78993