Wanatpreeya PhongsamartSomporn SrifeungfungSurang DejsirilertTanittha ChatsuwanPongpun NunthapisudVipa TreerauthaweeraphongPimpha RungnobhakhunKulkanya ChokephaibulkitMahidol University2018-08-242018-08-242007-01-26Vaccine. Vol.25, No.7 (2007), 1275-12800264410X2-s2.0-33845883019https://repository.li.mahidol.ac.th/handle/20.500.14594/24261In order to predict the potential benefit of pneumococcal conjugate vaccines (PCV), we evaluated the serotype coverage of the 7-, 9-, 11- and 13-valent PCV over the isolates causing invasive pneumococcal disease (IPD) in Thai children. One hundred and fifteen Streptococcus pneumoniae isolates from sterile sites in children younger than 5 years old between 2000 and 2005 were serotyped. The coverages of 7-, 9-, 11-, and 13-valent PCV were 69%, 73.8%, 73.8% and 85.7% in children younger than 2 years, and 73.9%, 77.4%, 77.4% and 87.8% in children younger than 5 years of age, respectively. 69.6% and 22.6% of the isolates were non-susceptible to penicillin and cefotaxime. 7-valent PCV covered 89% and 100% of penicillin and cefotaxime non-susceptible isolates. © 2006 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicineVeterinaryArticleSCOPUS10.1016/j.vaccine.2006.10.001