M. MøllerP. Phansuwan-PujitoP. GovitrapongP. SchmidtInstitute of Medical AnatomyKobenhavns UniversitetSrinakharinwirot UniversityMahidol University2018-08-102018-08-101993-05-21Brain Research. Vol.611, No.2 (1993), 347-351000689932-s2.0-0027174801https://repository.li.mahidol.ac.th/handle/20.500.14594/22534An antiserum, raised in rabbits, against substance P was used in an immunohistochemical investigation of the bovine pineal gland. A moderate innervation of all parts of the bovine pineal gland with subtance P-immunoreactive nerve fibers was demonstrated. The immunoreactive nerve fibers were located throughout the pineal gland, both perivascularly, intraparenchymally, and with few fibers in the pineal capsule. Within the habenular nucleus, a large number of substance substance P-immunoreactive perikarya were present. From these perikarya processes extended towards the pineal stalk and gland. Some substance P-immunoreactive nerve fibers were located in the stria medullaris and in the posterior commissure. The anatomical location of the substance P-immunoreactive nerve fibers in the pineal gland and stalk strongly indicates that, in this species, subtance P-immunoreactive pinealopetal nerve fibers originate from perikarya in the brain, probably from the medial habenular nucleus. © 1993.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineNeuroscienceArticleSCOPUS10.1016/0006-8993(93)90525-R