Putipun PuataweepongJiamjit TapaneeyakornSurasak LeelaudomlipiAbhasnee SobhonslidsukPornpan YongvithisatidMahidol University2018-09-132018-09-132009-12-01Asian Biomedicine. Vol.3, No.6 (2009), 689-692190574152-s2.0-79952121676https://repository.li.mahidol.ac.th/handle/20.500.14594/27101Background: CyberKnife is a frameless image-guided robotic system for stereotactic body radiotherapy. It can deliver an accurate and concentrated radiation beam to intracranial and extracranial targets for benign, malignant and some non-neoplastic conditions. Objective: To report the first hepatocellular carcinoma (HCC) treated with CyberKnife at Ramathibodi Hospital. Patient and methods: A 73-year-old man with a large right lobe hepatocellular carcinoma was treated with CyberKnife with the total dose of 4500 cGy in three fractions. Results: Two weeks after CyberKnife, he developed radiation induced liver damage (RILD). The patient was admitted for observation and supportive treatment. He was discharged with much improvement of symptoms. Abdominal MRI taken 1 and 3 months after the CyberKnife revealed a significant reduction in size of HCC. His serum alpha fetoprotein was also decreased from 833 ng/mLto 12 ng/mL. Conclusion: The present Robotic Radiosurgery was an effective alternative treatment for HCC. Early detection and proper supportive care was very important to decrease the morbidity from this serious radiation.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS