P. PitisuttithumS. MigasenaP. SuntharasamaiW. SupanaranondV. DesakornB. PrayurahongMahidol University2018-06-142018-06-141989-06-01The Southeast Asian journal of tropical medicine and public health. Vol.20, No.2 (1989), 201-205012515622-s2.0-0024675169https://repository.li.mahidol.ac.th/handle/20.500.14594/15812Immunogenicity of killed whole vibrio and B subunit oral cholera vaccines in American and Thai volunteers were analysed in terms of significant rise of antibody titre. Three doses of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit were given at two-week intervals. There were no differences in the percent of volunteers with significant rise of serum immunoglobulin G and secretory immunoglobulin A (sIgA) to cholera toxin. However, the percent with significant rises of serum antibody to whole cell V. cholerae Inaba measured by vibriocidal titre and serum immunoglobulin G, and secretory immunoglobulin A to lipopolysaccharide (LPS) measured by ELISA in American volunteers were significantly different from those in Thai volunteers (89% VS 45%, 68% VS 9% and 53% VS 0%, respectively) (p less than 0.05).Mahidol UniversityMedicineArticleSCOPUS