Nottasorn PlipatGilat LivniHeidi BertramRichard B. ThomsonMahidol UniversitySchneider Childrens Medical Center IsraelDepartment of Pathology and Laboratory MedicineNorthwestern University Feinberg School of Medicine2018-06-212018-06-212005-05-01Journal of Clinical Microbiology. Vol.43, No.5 (2005), 2494-2496009511372-s2.0-18544374025https://repository.li.mahidol.ac.th/handle/20.500.14594/16994We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure. Copyright © 2005, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicineArticleSCOPUS10.1128/JCM.43.5.2494-2496.2005