Sirima SoodvilaiSunhapas SoodvilaiWarayuth SajomsangTheerasak RojanarataPrasopchai PatrojanasophonPraneet OpanasopitRangsit UniversitySilpakorn UniversityThailand National Nanotechnology CenterMahidol University2020-08-252020-08-252020-09-15ACM International Conference Proceeding Series. (2020), 197-2012-s2.0-85088159390https://repository.li.mahidol.ac.th/handle/20.500.14594/57818© 2020 ACM. This research aimed to determine the influence of chitosan derivatives, N-octyl-N,O-succinyl chitosan (OSCS), on prevention of cisplatin-induced nephrotoxicity and anticancer activity of cisplatin. The OSCS blank micelles was prepared by a dialysis approach. The OSCS polymeric micelles were successfully complexed with cisplatin. Cisplatin treatment significantly increased apoptotic cells compared with control. OSCS micelles were able to protect the cells against cisplatin-induced cytotoxicity. The result revealed that OSCS micelles decreased the nephrotoxicity without reversing activity of cisplatin in cancer cells. In addition, cisplatin-OSCS complex showed less toxicity in renal proximal tubular cells than cisplatin alone. Its anti-cancer activity was favorable but less potent than cisplatin alone. In conclusion, the present study demonstrates that the chitosan derivative, OSCS, might be developed as nephroprotective agent for cisplatin treatment.Mahidol UniversityComputer ScienceConference PaperSCOPUS10.1145/3397391.3397438