Surapol IssaragrisilKanchana ChansungDavid W. KaufmanJittima SirijirachaiTharatorn ThamprasitNeal S. YoungMahidol UniversityKhon Kaen UniversityBoston University - Slone Epidemiology UnitPrince of Songkla UniversityNational Heart, Lung, and Blood Institute2018-07-042018-07-041997-01-01American Journal of Public Health. Vol.87, No.9 (1997), 1551-1554009000362-s2.0-0030801970https://repository.li.mahidol.ac.th/handle/20.500.14594/18217Objectives. A population-based case-control study was conducted to elucidate the incidence and etiology o aplastic anemia in Thailand. Methods. Case patients and hospital control patients were enrolled in three regions from 1989 to 1994; data were collected by interview. Results. Forty-six percent of 81 case patients and 19% of 295 control patients from Khonkaen were grain farmers (estimated relative risk [RR] = 2.7, 95% confidence interval [CI] = 1.4, 5.2). Sixteen percent of case patients and 6% of control patients used agricultural pesticides (estimated RR= 2.7, 95% CI= 1.1, 6.6). The association with grain farming remained among those not exposed to pesticides. In Songkla, 16% of 43 case patients and 2% of 181 control patients were grain farmers (crude RR estimate = 11, 95% CI = 3.4, 35). Conclusions. The relation of aplastic anemia to grain farming may partly explain the high incidence of aplastic anemia in Thailand.Mahidol UniversityMedicineArticleSCOPUS10.2105/AJPH.87.9.1551