Takashi NakanoShingo KatoJianping CaoJuying ZhouRaden SusworoNana SuprianaShinichiro SatoTatsuya OhnoHisao SutoYuzuru NakamuraChul Koo ChoFuad B. IsmailMiriam J.C. CalaguasRey H. de los ReyesYaowalak ChansilpaKullathom ThephamongkholNguyen Ba DucTo Anh DungHirohiko TsujiiGunma University Faculty of MedicineNational Institute of Radiological Sciences ChibaSoochow UniversityUniversity of Indonesia, RSUPN Dr. Cipto MangunkusumoMatsudo City HospitalSaitma Medical University Faculty of MedicineKorea Cancer Center HospitalHospital Universiti Kebangsaan MalaysiaSt. Luke's Medical Center Quezon CityJose R. Reyes Memorial Medical CenterMahidol UniversityNational Cancer Institute Hanoi2018-08-242018-08-242007-09-01Radiotherapy and Oncology. Vol.84, No.3 (2007), 314-319016781402-s2.0-34548427030https://repository.li.mahidol.ac.th/handle/123456789/24780Purpose: Radiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted. Materials and methods: Eleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50 Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28 Gy/4 fractions for HDR-ICBT and 30-40 Gy/1-2 fractions for LDR-ICBT. Results: Hundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32 Gy in the HDR group and 26-52.7 Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group. Conclusions: Although there were several problems with treatment compliance and patients' follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia. © 2007 Elsevier Ireland Ltd. All rights reserved.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.radonc.2007.05.012