Daniela A. WilsonKaterina A. AndreopoulouMihai PetercaPawaret LeowanawatDipankar SahooBenjamin E. PartridgeQi XiaoNing HuangPaul A. HeineyVirgil PercecPanepistimion PatronStony Brook UniversityRadboud University NijmegenMahidol UniversityUniversity of Pennsylvania2020-01-272020-01-272019-04-17Journal of the American Chemical Society. Vol.141, No.15 (2019), 6162-616615205126000278632-s2.0-85064567072https://repository.li.mahidol.ac.th/handle/20.500.14594/50200© 2019 American Chemical Society. Frank-Kasper phases and liquid quasicrystals self-organize from supramolecular spheres of dendrimers, block copolymers, surfactants and other self-assembling molecules. These spheres are expected to be achiral due to their isotropic shape. Nevertheless, supramolecular spheres from short helical stacks of crown-like dendrimers self-organize a Pm3n cubic (Frank-Kasper A15) phase which exhibits chirality on the macroscopic scale. However, the chirality of classic isotropic supramolecular micellar-like spheres, generated from conical dendrons, is unknown. Here we report a library of second and third generation biphenylpropyl dendrons with chiral groups at their apex that produces single-handed chiral supramolecular spheres. Up to 480 conical dendrons self-assemble to form micellar-like spheres, with a molar mass of up to 1.1 × 106 g/mol, that self-organize into a Pm3n phase with chirality detectable on the macroscopic scale. This demonstration of chirality in micellar-like spheres of a Frank-Kasper phase raises the fundamental question whether micellar-like spheres forming 3D phases generated from other soft matter such as block copolymers, surfactants, and other molecules are chiral.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemical EngineeringChemistryArticleSCOPUS10.1021/jacs.9b02206