Lim L.L.S. H. Lau E.Pheng Chan S.Ji L.Lim S.Sirinvaravong S.Unnikrishnan A.G.O. Y. Luk A.Cortese V.Durocher A.C. N. Chan J.Mahidol University2023-09-102023-09-102023-09-01Diabetes Research and Clinical Practice Vol.203 (2023)01688227https://repository.li.mahidol.ac.th/handle/123456789/89588Aims: To describe health-related quality of life (HRQoL) and identify associated factors in patients with type 2 diabetes mellitus (T2DM) treated with oral glucose-lowering drugs (OGLDs). Methods: This retrospective, cross-sectional analysis included adults with T2DM from 11 Asian countries/regions prospectively enrolled in the Joint Asian Diabetes Evaluation (JADE) Register (2007–2019) with available EuroQol-5D (EQ-5D-3L) data. Results: Of 47,895 included patients, 42,813 were treated with OGLDs + lifestyle modifications (LSM) and 5,082 with LSM only. Among those treated with OGLDs, 60% received sulphonylureas (SUs), of whom 47% received gliclazide. The OGLD + LSM group had a lower mean EQ-5D-3L index score than the LSM-only group (p < 0.001). The most affected EQ-5D-3L dimensions in OGLD + LSM-treated patients were pain/discomfort (26.2%) and anxiety/depression (22.6%). On multivariate analysis, good HRQoL was positively associated with male sex, education level, balanced diet and regular exercise, and negatively with complications/comorbidities, self-reported hypoglycaemia, smoking, HbA1c, age, body mass index and disease duration. Patients receiving gliclazide vs non-gliclazide SUs had lower HbA1c and better HRQoL in all dimensions (p < 0.001). Conclusions: Demographic, physical and psychosocial-behavioural factors were associated with HRQoL in patients with T2DM. Our real-world data add to previous evidence that gliclazide is an effective OGLD, with most treated patients reporting good HRQoL. A plain language summary of this manuscript is available here.Biochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.diabres.2023.1108552-s2.0-851685174881872822737517776