K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Aoli XiongPrem PrakashXiaohong GaoMarvin ChewIan Jun Jie TayCharles J. WoodrowBevin P. EngelwardJongyoon HanPeter R. PreiserSingapore-MIT Alliance for Research and TechnologySchool of Biological SciencesMassachusetts Institute of TechnologyMahidol University2020-08-252020-08-252020-08-04Cell Reports. Vol.32, No.5 (2020)221112472-s2.0-85088856605https://repository.li.mahidol.ac.th/handle/20.500.14594/57689© 2020 The Author(s) Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyK13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage RepairArticleSCOPUS10.1016/j.celrep.2020.107996