M. L. ArnoldF. M. HeinemannP. HornM. ZiemannN. LachmannA. MühlbacherA. DickA. EnderD. ThammanichanondG. F. FischerS. SchaubM. HallenslebenJ. MytilineosW. E. HitzlerC. SeidlI. I.N. DoxiadisB. M. SpriewaldFriedrich-Alexander-Universität Erlangen-NürnbergUniversitats Klinikum Essen und Medizinische FakultatUniversitatsklinikum Schleswig-Holstein Campus LubeckCharité – Universitätsmedizin BerlinUniversity Hospital InnsbruckKlinikum der Universitat MunchenKlinikum Stuttgart KatharinenhospitalMahidol UniversityMedizinische Universitat WienUniversitatsspital BaselMedizinische Hochschule Hannover (MHH)Universitatsklinikum UlmKlinikum der Johannes-Gutenberg-Universitat und Fachbereich MedizinInstitute for Transfusion Medicine and ImmunohaematologyLeiden University Medical Center - LUMC2018-10-192018-10-192013-02-01International Journal of Immunogenetics. Vol.40, No.1 (2013), 17-201744313X174431212-s2.0-84872264921https://repository.li.mahidol.ac.th/handle/123456789/31374In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti-HLA alloantibodies of the IgA isotype using a modified microsphere-based platform. Of the kidney recipients, nearly one-third (n = 237, 31%) had IgA alloantibodies. Mostly, these antibodies were found in sera that also harboured IgG alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, IgA anti-HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the IgG isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the IgA alloantibodies could be established for over half of the 237 patients with IgA alloantibodies (n = 124, 52%). A further 58 patients had specificities against HLA-C or HLA-DP, for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that IgA alloantibodies occur in about one-third of patients, about half of these antibodies being donor specific. © 2012 Blackwell Publishing Ltd.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicineConference PaperSCOPUS10.1111/iji.12032