Mahmood Ameen AbdullaIkhlak AhmedAnunchai AssawamakinJong BhakSamir K. BrahmachariGayvelline C. CalacalAmit ChaurasiaChien Hsiun ChenJieming ChenYuan Tsong ChenJiayou ChuEva Maria C. Cutiongco-de La PazMaria Corazon A. De UngriaFrederick C. DelfinJuli EdoSuthat FuchareonHo GhangTakashi GojoboriJunsong HanSheng Feng HoBoon Peng HohWei HuangHidetoshi InokoPankaj JhaTimothy A. JinamLi JinJongsun JungDaoroong KangwanpongJatupol KampuansaiGiulia C. KennedyPreeti KhuranaHyung Lae KimKwangjoong KimSangsoo KimWoo Yeon KimKuchan KimmRyosuke KimuraTomohiro KoikeSupasak KulawonganunchaiVikrant KumarPoh San LaiJong Young LeeSunghoon LeeEdison T. LiuPartha P. MajumderKiran Kumar MandapatiSangkot MarzukiWayne MitchellMitali MukerjiKenji NaritomiChumpol NgamphiwNorio NiikawaNao NishidaBermseok OhSangho OhJun OhashiAkira OkaRick OngCarmencita D. PadillaPrasit PalittapongarnpimHenry B. PerdigonMaude Elvira PhippsEileen PngYoshiyuki SakakiJazelyn M. SalvadorYuliana SandralingVinod ScariaMark SeielstadMohd Ros SidekAmit SinhaMetawee SrikummoolHerawati SudoyoSumio SuganoHelena SuryadiYoshiyuki SuzukiKristina A. TabbadaAdrian TanKatsushi TokunagaSissades TongsimaLilian P. VillamorEric WangYing WangHaifeng WangJer Yuarn WuHuasheng XiaoShuhua XuJin Ok YangYin Yao ShugartHyang Sook YooWentao YuanGuoping ZhaoBin Alwi ZilfalilUniversity of MalayaInstitute of Genomics and Integrative Biology IndiaMahidol UniversityThailand National Center for Genetic Engineering and BiotechnologyKorea Research Institute of Bioscience and BiotechnologyUniversity of the Philippines DilimanInstitute of Biomedical Sciences Academia Sinica TaiwanGenome Institute of SingaporeChinese Academy of Medical SciencesUniversity of the Philippines ManilaResearch Organization of Information and SystemsNational Institute of Advanced Industrial Science and TechnologyNational Engineering Center for Biochip at ShanghaiSchool of Medical Sciences - Universiti Sains MalaysiaChinese National Human Genome Center at ShanghaiTokai University School of MedicineFudan UniversityKorea National Institute of HealthChiang Mai UniversityThermo Fisher ScientificVeracyte, Inc.Soongsil UniversityEulji UniversityUniversity of TokyoYong Loo Lin School of MedicineDSO National LaboratoriesIndian Statistical Institute, KolkataEijkman Institute for Molecular BiologyExperimental Therapeutics CentreNanyang Technological University School of Computer EngineeringUniversity of the Ryukyus Faculty of MedicineThailand National Science and Technology Development AgencyMonash University MalaysiaRIKEN Genomic Sciences CenterShanghai Institute for Biological Sciences Chinese Academy of SciencesNational Institute of Mental HealthHealth Sciences University of Hokkaido2018-09-132018-09-132009-12-11Science. Vol.326, No.5959 (2009), 1541-154510959203003680752-s2.0-72149083621https://repository.li.mahidol.ac.th/handle/20.500.14594/28380Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.Mahidol UniversityMultidisciplinaryArticleSCOPUS10.1126/science.1177074