Sunee SirivichayakulWasan ChantratitaRuengpung SutthentKiat RuxrungthamPraphan PhanuphakRobert B. OelrichsChulalongkorn UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMahidol UniversityThai Red Cross AIDS Research CentreMacfarlane Burnet Institute for Medical Research2018-09-072018-09-072001-07-20AIDS Research and Human Retroviruses. Vol.17, No.11 (2001), 1077-1081088922292-s2.0-0034835567https://repository.li.mahidol.ac.th/handle/20.500.14594/26561Genetic diversity of the HIV-1 envelope gene has shown a steady increase over time in the Thai and other regional epidemics. A serial survey of subtype CRF01_AE polymerase gene (RT) diversity in Thailand was performed, using 48 novel and 15 reported sequences covering the period 1990-2000. These sequences were gathered from individuals whose sole risk factor for infection was heterosexual contact. By contrast to envelope, diversity was low and, despite a 40% increase early in the epidemic, has remained static since 1996. These results indicate that epidemic HIV-1 may be constrained within defined limits of genetic diversity at least in some genomic regions. © 2001 Mary Ann Liebert, Inc.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1089/088922201300343762