Saposnik G.Nilanont Y.Johnston S.C.Mahidol University2026-02-062026-02-062026-01-01Stroke Vol.57 No.1 (2026) , 230-244https://repository.li.mahidol.ac.th/handle/123456789/114470Over the past 10 years, stroke care has seen remarkable technological and pharmacological breakthroughs-ranging from advanced thrombectomy devices and streamlined thrombolytic therapies like tenecteplase to artificial intelligence-powered imaging and rehabilitation tools. Yet adoptions remain uneven due to fragmented systems, low adherence, and inconsistent implementation. To overcome these barriers, neuroeconomics-a multifaceted integration of neuroscience, behavioral economics, psychology, and clinical medicine-sharpens decision-making under uncertainty and drives sustained behavior change. Behavioral economics offers a toolkit of low-cost, scalable interventions-nudges, default options, framing effects, commitment devices, incentives, gamification, and social-norm feedback-that can be woven into every phase of stroke management. Embedding preselected treatment orders in electronic health records, default-scheduling follow-up appointments, and delivering tailored digital reminders have all boosted adherence to medications, rehabilitation exercises, and preventive measures. Financial rewards and community-based feedback loops have improved both clinicians' prescribing habits and patient self-management. Early pilot programs demonstrate that even small tweaks in workflow or choice architecture can yield outsized improvements in timely reperfusion, secondary prevention uptake, and long-term outcomes. By embedding evidence-based interventions directly into care decisions, the integration of neuroeconomic principles helps bridge the gap between scientific innovation and its transformative impact on patient outcomes.NursingMedicineReviewSCOPUS10.1161/STROKEAHA.125.0507522-s2.0-1050256654331524462841111419