Puangtong KraiphibulSomkeart SrisupunditVirat PairachvetSomjai KiatgumjaikajornChirapha TannanontaMahidol University2018-08-102018-08-101992-01-01Gynecologic Oncology. Vol.45, No.2 (1992), 160-16310956859009082582-s2.0-0026749887https://repository.li.mahidol.ac.th/handle/20.500.14594/22431To compare the results of treatment in stage IIB squamous cell carcinoma of the uterine cervix of two treatment regimens, two radium insertions vs one insertion, a prospective randomized study was carried out at Ramathibodi Hospital from 1 January 1983 to 31 December 1986, and the results were evaluated at the end of March 1991. The patients in treatment I (90 cases) received 40-41.4 Gy whole pelvic external irradiation and two intracavitary radium insertions, while patients in treatment II (53 cases) received 50.0-50.4 Gy and one intracavitary insertion. Both groups received the same total dose at point A, about 85-90 Gy. At 4 and 5 years, by the Kaplan-Meier survival curve, the diseasefree survivals were 76 and 76% vs 79 and 79%, respectively, in treatment I and treatment II, which showed no significant difference by the log-rank test. Both groups had comparable serious complication rates, 0% vs 1.9%, respectively. However, grade I complications in treatment II, 35.8%, were higher than those in treatment I, 17.8% (P < 0.01). Therefore, we concluded that treatment II provided the same disease-free survival and a very low rate of serious complications. To replace treatment I, the dose at the rectum and urinary bladder should be maintained with caution. © 1992.Mahidol UniversityMedicineArticleSCOPUS10.1016/0090-8258(92)90279-R