A. R. PantS. M. GrahamS. J. AllenS. HarikulA. SabchareonL. CuevasC. A. HartLiverpool School of Tropical MedicineMahidol UniversityUniversity of Liverpool2018-07-042018-07-041996-01-01Journal of Tropical Pediatrics. Vol.42, No.3 (1996), 162-165014263382-s2.0-0029946140https://repository.li.mahidol.ac.th/handle/20.500.14594/17811A prospective, placebo controlled, triple blind clinical trial was undertaken in Thailand to determine the effect of Lactobacillus GG on recovery from acute diarrhoea in children. Thirty-nine children (mean age = 8 months) were enrolled and following rehydration received either oral Lactobacillus GG (n = 20) as a freeze-dried preparation or placebo (n = 19) twice daily for 2 days. The clinical characteristics of the study groups were similar. There was no significant difference overall in clinical response detected between the study groups. When only those with acute non-bloody diarrhoea (n = 26) were considered, the mean duration of diarrhoea was significantly shorter in the lactobacillus group (1.9 days) than in the placebo group (3.3 days) (P < 0.055). Stool frequency was less on the second day in the lactobacillus group (P < 0.05). The results suggest that Lactobacillus GG accelerates recovery from acute watery diarrhoea in young children in a tropical setting.Mahidol UniversityMedicineArticleSCOPUS10.1093/tropej/42.3.162