Alisa TubsuwanCarlota PiresMikkel A. RasmussenBenjamin SchmidJørgen E. NielsenLena E. HjermindVanessa HallTroels T. NielsenGunhild WaldemarPoul HyttelChristian ClausenNarisorn KitiyanantKristine K. FreudeBjørn HolstMahidol UniversityKøbenhavns UniversitetBioneer AS2018-12-112019-03-142018-12-112019-03-142016-01-01Stem Cell Research. Vol.16, No.1 (2016), 110-11218767753187350612-s2.0-84952801845https://repository.li.mahidol.ac.th/handle/20.500.14594/43174© 2015. Induced pluripotent stem cells (iPSCs) were generated from skin fibroblasts isolated from a 58-year old male with a L150P mutation in the presenilin 1 (PSEN-1) gene, which is responsible for the majority of familial cases of Alzheimer's disease (AD). The iPSCs were established by co-electroporation with episomal plasmids containing hOCT4, hSOX2, hL-MYC, hKLF4, hNANOG, hLIN28, and short hairpin RNA against TP53. The iPSCs contained the specific heterozygous mutation c.449C > T, had normal karyotype, expressed the expected pluripotency genes and displayed in vitro differentiation potential to the three germ layers. The iPSCs may be useful for studying familial AD pathology in vitro.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.scr.2015.12.015