O. ThonggoomN. PunrattanasinN. SrisawangN. PromawanR. ThonggoomThammasat UniversityMahidol University2018-12-112019-03-142018-12-112019-03-142016-04-02Journal of Microencapsulation. Vol.33, No.3 (2016), 239-24814645246026520482-s2.0-84961149423https://repository.li.mahidol.ac.th/handle/123456789/43379© 2016 Informa UK Limited, trading as Taylor & Francis Group. In this study, a micellar delivery system with an amphiphilic diblock copolymer of poly (ethylene glycol) and poly (ɛ-caprolactone) was synthesised and used to incorporate hydrophobic clove essential oil (CEO). To determine an optimal delivery system, the effects of the copolymer’s hydrophobic block length and the CEO-loading content on the encapsulation of CEO were investigated. Percentages of entrapment efficiency (%EE), CEO loading (%CEO), and in vitro release profiles were determined. The size, size distribution, zeta potential, and morphology of the obtained micelles were determined by DLS, FE-SEM, and TEM. The %EE, %CEO, and in vitro release profiles of CEO incorporated in micelles were analysed by HPLC. The study revealed a sustained release profile of CEO from CEO-loaded micelles. The results indicate the successful formulation of CEO-loaded PEG-b-PCL micelle nanoparticles. It is suggested that this micelle system has considerably potential applications in the sustained release of CEO in intravascular drug delivery.Mahidol UniversityChemical EngineeringChemistryArticleSCOPUS10.3109/02652048.2016.1156173