Xinda ZouAmrit BKTareq Abu-IzneidAhsan AzizPopy DevnathAbdur RaufSaikat MitraTalha Bin EmranAdil A.H. MujawahJose M. LorenzoMohammad S. MubarakPolrat WilairatanaHafiz A.R. SuleriaFaculty of Tropical Medicine, Mahidol UniversityUniversity of SwabiFundación Centro Tecnolóxico da CarneNoakhali Science and Technology UniversityAl Ain UniversityThe University of JordanFaculty of Veterinary and Agricultural SciencesUniversidade de VigoAl Qassim UniversityUniversity of DhakaBGC Trust University Bangladesh2022-08-042022-08-042021-11-01Biomedicine and Pharmacotherapy. Vol.143, (2021)19506007075333222-s2.0-85115432805https://repository.li.mahidol.ac.th/handle/123456789/78940Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials that are rarely recycled. In recent years, numerous potential bioactive compounds have been isolated from tobacco, and the molecular regulatory mechanisms related to the performance of some functionalities have been identified. This review describes the source of tobacco waste and expounds a large amount of biomass during the tobacco processing, and the necessity of exploring the reuse of tobacco waste. In addition, the review summarizes the bioactive compounds from tobacco that have been discovered so far, and links them to various functions from tobacco extracts, including anti-inflammatory, antitumor, antibacterial, and antioxidant, thus proving the potential value from tobacco waste reuse. In this regard, nornicotine in tobacco is the culprit of many health issues, while the polyphenols and polysaccharides often contribute to the health benefits of tobacco extract. In addition, it is hard to ignore that realization of these functions of tobacco extracts require the involvement of intestinal flora metabolism, which should be considered in the development of new product dosage forms.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsReviewSCOPUS10.1016/j.biopha.2021.112191