K. ChokephaibulkitG. HouillonE. FeroldiA. BouckenoogheMahidol UniversitySanofi Pasteur SAClinical Sciences and Medical Affairs Asia2018-12-112019-03-142018-12-112019-03-142016-02-01Expert Review of Vaccines. Vol.15, No.2 (2016), 153-16617448395147605842-s2.0-84955670544https://repository.li.mahidol.ac.th/handle/20.500.14594/43152© 2015 Taylor & Francis. JE-CV (IMOJEV®, Sanofi Pasteur, France) is a live attenuated virus vaccine constructed by inserting coding sequences of the prM and E structural proteins of the Japanese encephalitis SA14-14-2 virus into the genome of yellow fever 17D virus. Primary immunization with JE-CV requires a single dose of the vaccine. This article reviews clinical trials of JE-CV in children aged up to 6 years conducted in countries across South-East Asia. Strong and persistent antibody responses were observed after single primary and booster doses, with 97% of children seroprotected up to five years after booster vaccination. Models of long-term antibody persistence predict a median duration of protection of approximately 30 years after a booster dose. The safety and reactogenicity profiles of JE-CV primary and booster doses are comparable to other widely used childhood vaccines.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyReviewSCOPUS10.1586/14760584.2016.1123097