Magdalena Anna MalinowskaKévin BilletSamantha DrouetThibaut MunschMarianne UnlubayirDuangjai TungmunnithumNathalie Giglioli-Guivarc'HChristophe HanoArnaud LanoueBiomolécules et Biotechnologies Végétales (BBV)Universite d'OrleansPolitechnika KrakowskaMahidol University2020-06-022020-06-022020-05-01Molecules. Vol.25, No.9 (2020)142030492-s2.0-85084457027https://repository.li.mahidol.ac.th/handle/123456789/56121© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Grape canes are waste biomass of viticulture containing bioactive polyphenols valuable in cosmetics. Whereas several studies reported the cosmetic activities of E-resveratrol, only few described the potential of E-ϵ-viniferin, the second major constituent of grape cane extracts (GCE), and none of them investigated GCE as a natural blend of polyphenols for cosmetic applications. In this study, we considered the potential of GCE from polyphenol-rich grape varieties as multifunctional cosmetic ingredients. HPLC analysis was performed to quantify major polyphenols in GCE i.e., catechin, epicatechin, E-resveratrol, E-piceatannol, ampelopsin A, E-ϵ-viniferin, hopeaphenol, isohopeaphenol, E-miyabenol C and E-vitisin B from selected cultivars. Skin whitening potential through tyrosinase inhibition assay and the activation capacity of cell longevity protein (SIRT1) of GCE were compared to pure E-resveratrol and E-ϵ-viniferin. Drug-likeness of GCE polyphenols were calculated, allowing the prediction of skin permeability and bioavailability. Finally, the present data enabled the consideration of GCE frompolyphenol-rich varieties asmultifunctional cosmetic ingredients in accordance with green chemistry practices.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.3390/molecules25092203