Guido B. MarcelleNuntavan BunyapraphatsaraGeoffrey A. CordellHarry H.S. FongKyriakos C. NicolaouRobert E. ZipkinUniversity of Illinois at ChicagoMahidol UniversityUniversity of Pennsylvania2018-10-122018-10-121985-01-01Journal of Natural Products. Vol.48, No.5 (1985), 739-74515206025016338642-s2.0-0022359390https://repository.li.mahidol.ac.th/handle/20.500.14594/30762Hot H2O and hexane were found to be inappropriate to extract zoapatanol (1) from the leaves of Montanoa tomentosa ssp. tomentosa; EtOH and EtOAc, on the other hand, were far more effective. A number of Montanoa species and subspecies were examined for the presence of zoapatanol (1). Zoapatanol is highly unstable either neat or in aqueous solution at elevated temperatures, and only samples dissolved in solvent and stored at — 5 to — 10° have extended half-lives. The initial decomposition product of zoapatanol (1) has been identified as 21-normontanol (2) through high field proton nmr analysis. © 1985, American Chemical Society. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np50041a004