Yazli YuhanaAmpai TanganuchitcharnchaiPimpan SujariyakulPiengchan SonthayanonKesinee ChotivanichDaniel H. ParisSasithon PukrittayakameeStuart D. BlacksellBorimas HanboonkunupakarnUniversitat BaselSwiss Tropical and Public Health Institute (Swiss TPH)Mahidol UniversityNuffield Department of Clinical MedicineUniversiti Teknologi MARA2020-01-272020-01-272019-01-01Tropical Medicine and Infectious Disease. Vol.4, No.1 (2019)241463662-s2.0-85075800736https://repository.li.mahidol.ac.th/handle/123456789/51149© 2019 by the authors. Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. This case highlights the importance of considering murine typhus as a diagnostic in cases of acute febrile illness in urban and sub-urban areas, such as that of in Peninsular Malaysia.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.3390/tropicalmed4010023