Jakrin KewcharoenPattara RattanawongChanavuth KanitsoraphanRaktham MekritthikraiNarut PrasitlumkumPrapaipan PutthapibanPoemlarp MekraksakitRobert J. PattisonWasawat VutthikraivitTexas Tech University Health Sciences Center at LubbockFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityUniversity of Hawaii at ManoaEinstein Medical Center2020-01-272020-01-272019-11-01Annals of Noninvasive Electrocardiology. Vol.24, No.6 (2019)1542474X1082720X2-s2.0-85070326904https://repository.li.mahidol.ac.th/handle/123456789/51339© 2019 Wiley Periodicals, Inc. Background: Brugada syndrome (BrS) is a common cause of sudden cardiac death (SCD). There is recent evidence that atrial fibrillation (AF) is associated with increased risk of SCD in general population. However, whether AF increases a risk of major arrhythmic events (MAE) in patients with BrS is still unclear. We performed a systematic review and meta-analysis to explore the effect of AF on MAE in BrS population. Methods: We searched the databases of MEDLINE and EMBASE from inception to March 2019. Included studies were published cohort studies reporting rates of MAE (ventricular fibrillation, sustained ventricular tachycardia, SCD, or sudden cardiac arrest) in BrS patients, with and without previous documented AF. Data from each study were combined using the random-effects model. Results: Six studies from 1,703 patients were included. There was a significant association between AF and an increased risk of MAE in patients with BrS (pooled OR = 2.37, 95% CI = 1.36–4.13, p-value =.002, I2 = 40.3%). Conclusions: Our meta-analysis demonstrated that AF is associated with an increased risk of MAE in patients with BrS.Mahidol UniversityMedicineArticleSCOPUS10.1111/anec.12676