V. SinghasivanonT. ChongsuphajaisiddhiA. SabcharoenP. AttanathH. K. WebsterW. H. WernsdorferU. K. ShethI. Djaja LikaMahidol UniversityArmed Forces Research Institute of Medical Sciences, ThailandOrganisation Mondiale de la Sante2018-08-102018-08-101992-10-01European Journal of Drug Metabolism and Pharmacokinetics. Vol.17, No.4 (1992), 275-27921070180037879662-s2.0-0027103175https://repository.li.mahidol.ac.th/handle/123456789/22372The study was carried out in 12 children aged 6 months to 2 years, with uncomplicated falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok. They were treated with mefloquine in the form of MSP (mefloquine 2S0 mg+sulfadoxine 500 mg +pyrimethamine 25 mg) at a single dose of 25 mg mefloquine base/kg body weight All of them were cured (28 days follow-up) with minimal side effects. Pharmacokinetic parameter determination was carried out in 9 cases. The results revealed that MRT, t1/2 and tmax in this study (children 6-24 months old) are comparable to the values in children aged 5-12 years, but shorter than in adult patients. Cmax and AUC in children 6-24 months old are comparable to those in children of 5-12 years, but much higher than in adult patients. Vz/f values in this study are comparable to those in children 5-12 years old, but lower than in adult patients. © 1992 Springer-Verlag.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1007/BF03190160