Kawin LeelawatSurang EngprasertUrai Pongchai-RerkSupatip TuchindaCheepsumon SuthipintawongVijittra LeardkamolkarnMahidol UniversityRajavithi HospitalKyushu University2018-07-242018-07-242004-07-01Journal of the Medical Association of Thailand. Vol.87, No.7 (2004), 816-818012522082-s2.0-4444248880https://repository.li.mahidol.ac.th/handle/123456789/21614Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.Mahidol UniversityMedicineArticleSCOPUS