Panomwan PanseetaKanlaya LomchoeySamran PrabpaiPalangpon KongsaereeApichart SuksamrarnSomsak RuchirawatSunit SuksamrarnSrinakharinwirot UniversityMahidol UniversityRamkhamhaeng UniversityChulabhorn Research Institute2018-05-032018-05-032011-06-01Phytochemistry. Vol.72, No.9 (2011), 909-915003194222-s2.0-79955757528https://repository.li.mahidol.ac.th/handle/20.500.14594/11316Investigation of the MeOH extract obtained from the root of the Ziziphus mauritiana grown in Thailand resulted in the isolation of two 14- and 13-membered cyclic alkaloids, mauritine L (1) and mauritine M (2), and three known cyclopeptide alkaloids, nummularines H (3), B (4) and hemsine A (5). Their structures were elucidated on the basis of extensive NMR spectroscopic analysis. The first single crystal X-ray diffraction study of the 13-membered ring cyclopeptide, nummularine B methiodide (4′), revealed all S configurations on the amino acid residues. The isolated alkaloids exhibited potent antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC 50 ) ranging from 3.7 to 10.3 μM. Compounds 2 and 3 also demonstrated antimycobacterial activity against Mycobacterium tuberculosis with the MIC of 72.8 and 4.5 μM, respectively. © 2011 Elsevier Ltd. All rights reserved.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/j.phytochem.2011.03.003