Supa PengpidKarl PeltzerIsareethika JayasvastiWichai AekplakornApa PuckpinyoPheeraya NanthananateAnutsara MansinTon-Duc-Thang UniversityUniversity of LimpopoMahidol UniversityBangkokthonburi University2020-01-272020-01-272019-01-01International Journal of General Medicine. Vol.12, (2019), 131-135117870742-s2.0-85067521641https://repository.li.mahidol.ac.th/handle/20.500.14594/52345© 2019 Pengpid et al. The aim of the study was to assess the 2-year effect of a community-based randomized controlled lifestyle intervention on glucose and blood pressure levels in Thailand. Participants (N=443, with prediabetes and/or prehypertension) received a six 2-hr group sessions lifestyle intervention (physical activity and nutrition) over 6 months. Measurements were at baseline, 12 months (89%) and at 24 months (84.7%). Statistically significant interaction effects on fasting plasma glucose and DBP at 12 months were not maintained at 24 months, while significant interaction effects were found on high-density lipoprotein and low-density lipoprotein cholesterol at 24 months. Improvements were found for fasting plasma glucose, SBP, DBP and total cholesterol, but no significant interaction effect was detected. The development of type 2 diabetes was higher in the control than in the intervention group, but it was not reaching significance (P=0.181), while 3.0% in the intervention group and 2.6% in the control group developed hypertension at 24 months. No significant group differences were found in psycho-behavioral variables. The lifestyle intervention did not provide additional benefits compared to the control group at 24-month follow-up. Trial registration number: TCTR20170721001.Mahidol UniversityMedicineArticleSCOPUS10.2147/IJGM.S200086