Xiang WuPrapon WilairatMei Lin GoNational University of SingaporeMahidol University2018-07-242018-07-242002-09-02Bioorganic and Medicinal Chemistry Letters. Vol.12, No.17 (2002), 2299-23020960894X2-s2.0-0037009255https://repository.li.mahidol.ac.th/handle/20.500.14594/20045A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50of 4.5 and 5.1 μM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. © 2002 Elsevier Science Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/S0960-894X(02)00430-4