Prasong TanmahasamutThanyarat WongwananurukMahidol University2018-09-242018-09-242010-09-01Case Reports in Oncology. Vol.3, No.3 (2010), 380-385166265752-s2.0-78751526394https://repository.li.mahidol.ac.th/handle/20.500.14594/29536A 20-year-old obese Thai woman with polycystic ovary syndrome and clinical stage I well-differentiated endometrial carcinoma denied surgical staging. Chest X-ray and magnetic resonance imaging of the whole abdomen suggested neither distance metastasis nor local invasion of the cancer. After 3 months of systemic progestin therapy with megestrol acetate (MA) 480 mg/day, the endometrial carcinoma persisted. The treatment was changed to a combination of levonorgestrel intrauterine system (LNG-IUS) and MA with a stepping-up from 160 to 480 mg/day. Complete remission was achieved at treatment month 9. Prevention of recurrence was provided using LNG-IUS plus MA 160 mg/day. Endometrial surveillance using trimonthly transvaginal ultrasonography and endometrial biopsy suggested no recurrence for at least 24 months after remission. © 2010 S. Karger AG, Basel.Mahidol UniversityMedicineReviewSCOPUS10.1159/000321731