Muenkaew Y.Tangbumrungtham N.Roongpuvapaht B.Tanjararak K.Mahidol University2023-06-182023-06-182023-03-01Clinical Otolaryngology Vol.48 No.2 (2023) , 286-29317494478https://repository.li.mahidol.ac.th/handle/20.500.14594/85129Objective: This study aims to compare the potential sinus distribution between high-volume nasal irrigation and nasal spray in chronic rhinosinusitis (CRS) patients who have not undergone sinus surgery. Design and Setting: A randomised clinical study was conducted at the Otolaryngology-Head & Neck Surgery Department, Ramathibodi Hospital, Faculty of Medicine, Mahidol University. Participants: Forty patients undergoing endoscopic sinus surgery (ESS) for CRS. Thirty-eight patients met the inclusion criteria and were randomly assigned to receive nasal irrigation or nasal spray mixed with fluorescein sodium preoperatively. Main Outcome Measures: The primary outcome was the mean difference in the staining score of fluorescein in all sinuses between the two groups. Results: The total fluorescein staining score for all sinuses in the nasal irrigation group was significantly higher than the score from the nasal spray group, with a mean difference score of 2.90, 95% confidence interval: 1.22–4.58, p =.001. The most significantly affected sinuses were the maxillary and the anterior ethmoid sinuses, while the frontal and sphenoid sinuses had only minimal staining from both techniques. Conclusion: Nasal irrigation is a potential route to deliver drugs into the sinus in unoperated CRS patients. However, it is not considered a superior method to nasal spray in the most challenging anatomical areas, that is, the frontal and sphenoid sinuses.MedicineArticleSCOPUS10.1111/coa.139512-s2.0-851315391211749448635638864