Weena JiratchariyakulPrimchanien MoongkarndiFrahm, A.W.วีณา จิรัจฉริยากูลOkabe, H.ปริ่มเฉนียน มุ่งการดีMahidol University. Faculty of Pharmacy.2010-03-312011-08-292021-05-072010-03-312011-08-292021-05-072010-03-311998Thai Journal of Phytopharmacy. 1998; Vol.5, No.1 (1998), 10-20.0858-9399https://repository.li.mahidol.ac.th/handle/123456789/62113Murdannia lorifurmis (Hassk.) Rolla Rao et Kammathy has been traditionally used in Thailand for the treatment of cancer. The present work was aimed at investigating the active principles of this plant. Successive extractions of the powdered drug with petroleum ether (40-60 C), chloroform and ethanol and repeated separation of the ethanolic extract on Diaion HP20 column gave the two c)rtotoxic fractions, namely the methanolic and ethyl acetate fractions. The methanolic fraction was found to contain an active glycosphingolipid, named 1-beta-O-D-glucopyranosyl-2-(2'-hydroxy-6'-ene-cosamide)-sphingosine. The glycosphingolipid exerted a cytotoxicity effect (EDroof l6 micro/ml) against human colon carcinoma (SW 620) and human breast cancer ATCC HTB20 (BT 474) cell lines.509 KBapplication/pdfengMahidol UniversityMurdannia loriformisGlycosphingolipidCytotoxinsAnticancerหญ้าปักกิ่งResearch ArticleFaculty of Pharmacy Mahidol University