Jaray JaratjaroonphongSuppachai KrajangsriVichai ReutrakulBurapha UniversityMahidol University2018-06-112018-06-112012-05-09Tetrahedron Letters. Vol.53, No.19 (2012), 2476-247918733581004040392-s2.0-84859507206https://repository.li.mahidol.ac.th/handle/123456789/13731Iodine is shown to be an efficient catalyst for a one-step, three-component aza-Friedel-Crafts reaction of activated arenes or heteroarenes with benzyl or tert-butyl carbamates in combination with a wide variety of aldehydes in toluene under 'open-flask' and mild conditions. In the presence of 5 mol % of iodine in toluene at room temperature, the reaction gives the corresponding N-CBz or N-Boc protected α-branched amines, selectively, in good to excellent yields. © 2012 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tetlet.2012.03.024