Pitipat KitpipatkunKripitch SutummapornKonosuke KatoTomoaki MurakamiKyoko KobayashiYasumoto NakazawaRyou TanakaMahidol UniversityTokyo University of Agriculture and TechnologyRajamangala University of Agriculture and Technology2022-08-042022-08-042021-10-01Journal of Biomaterials Applications. Vol.36, No.4 (2021), 701-71315308022088532822-s2.0-85102106903https://repository.li.mahidol.ac.th/handle/20.500.14594/76928Purpose: To understand the complication and histopathological characteristics between the Silk Fibroin/Polyurethanes (SF/PU) and the host response, and to unveil the compatibility of the patch in diabetes individuals. Methods: Rats were divided into DM and control (CT) groups, and the DM group was induced with streptozotocin. All groups underwent the SF/PU patch implantation in the abdominal aorta, and the implanted patches were evaluated at one, two, three, and four weeks after implantation. Results: DM group had more fibrosis formation and a delayed endothelialization compared to the CT group. There was no evidence of chronic inflammation in both DM and CT groups. Conclusions: Fibrosis in hyperglycemic individuals could promote the formation of new vascular structures in the implanted patch such as endothelial and vascular smooth muscle cells. In summary, the SF/PU patch was no serious complications when implanted under hyperglycemia, and the patch was suitable to implant in diabetes mellitus.Mahidol UniversityEngineeringMaterials ScienceArticleSCOPUS10.1177/0885328221999227