Amol C. ShettyChristopher G. JacobFang HuangYao LiSonia AgrawalDavid L. SaundersChanthap LonMark M. FukudaPascal RingwaldElizabeth A. AshleyKay Thwe HanTin Maung HlaingMyaing M. NyuntJoana C. SilvaKathleen E. StewartChristopher V. PloweTimothy D. O’ConnorShannon Takala-HarrisonHarald NoedlWasif A. KhanPaul NewtonMyat P. KyawNicholas J. WhiteArjen M. DondorpNicholas P. DayCharles J. WoodrowMehul DhordaM. Abul FaizRick M. FairhurstPharath LimRupam TripuraMayfong MayxayYe HtutFrancois NostenAung Pyae PhyoSasithon PukrittayakameeTran Tinh HienNguyen Thanh Thuy NhienOlugbenga A. MokuoluCaterina I. FanelloMarie A. OnyambokoMedizinische Universitat Wien, Zentrum für Pathophysiologie, Infektiologie und ImmunologieChinese Center for Disease Control and PreventionOrganisation Mondiale de la SantéUniversity of MarylandNational Institute of Allergy and Infectious DiseasesArmed Forces Research Institute of Medical Sciences, ThailandUniversity of Maryland School of MedicineMahidol UniversityUniversity of IlorinInternational Centre for Diarrhoeal Disease Research BangladeshNuffield Department of Clinical MedicineDuke UniversityWellcome Sanger InstituteUniversity of Health SciencesMalaria Research Group and Dev Care FoundationLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)Defence Services Medical Research CentreArmed Forces Research Institute of Medical SciencesWorldWide Antimalarial Resistance NetworkOxford University Clinical Research Unit (OUCRU)Ministry of Health2020-01-272020-01-272019-12-01Nature Communications. Vol.10, No.1 (2019)204117232-s2.0-85067602013https://repository.li.mahidol.ac.th/handle/20.500.14594/50027© 2019, The Author(s). Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1038/s41467-019-10121-3