S. PuengtomwatanakulS. SirisinhaMahidol University2018-02-272018-02-271986-01-01Proceedings of the Society for Experimental Biology and Medicine. Vol.182, No.4 (1986), 437-44215353699003797272-s2.0-0022453997https://repository.li.mahidol.ac.th/handle/20.500.14594/9670The effect of vitamin A deficiency on biliary secretion of IgA was investigated. Rats used in this study were rendered vitamin A deficient following withdrawal of retinoic acid from the diet of retinoate-cycled animals. This procedure allows a precise control of both the onset of deficiency and dietary protein-energy input. Defective synthesis and transport of IgA antibodies into the bile was evident when vitamin A-deficient rats (A-) were immunized by injections of either Brucella abortus or sheep red blood cells directly into the Peyer's patches. Antibody titers in the bile of A- animals were significantly lower than those of A+ controls (P < 0.01). These A- rats also had significantly lower levels of total IgA in the bile compared with A+ controls (P < 0.05). Moreover, the transport of labeled rat IgA injected intravenously was adversely affected in these animals. These results, together with our previous report on the impaired intestinal antibody in A- rats, clearly indicate that vitamin A deficiency interferes with the transport of IgA antibodies into the bile of these animals. © 1986, SAGE Publications. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.3181/00379727-182-42362