Patiyananuwat N.Chartpitak T.Tancharoen S.Nasongkla N.Mahidol University2023-10-192023-10-192023-01-01Proceedings of the IEEE Conference on Nanotechnology Vol.2023-July (2023) , 484-48919449399https://repository.li.mahidol.ac.th/handle/123456789/90564Dental implant infections are a leading cause of implant failure, causing inflammation and bone loss. To combat such infections, a potential solution is the application of a nano-coating technique that utilizes nanotechnology and a drug delivery system to coat the implant surface. This study aimed to coat dental implants with poly(ϵ-caprolactone) nanospheres (PCL-NPs) loaded with minocycline (MC), an antibacterial agent, using the Layer-by-Layer (LbL) coating technique involving dipping and spraying. The dental implants were coated for 30, 60, 90, and 120 cycles, respectively. The MC/PCL- NPs achieved drug-loading contents of 0.16 ± 0.03, 3.03 ± 0.99, 5.87 ± 0.69, and 6.48 ± 1.68 mg, respectively. The antibacterial study revealed that the release profile of minocycline from the coated dental implants effectively inhibited bacteria growth for a duration of three days. Keywords: Dental implant, nano-coating, nanospheres, poly(ϵ-caprolactone), minocycline, drug delivery systemChemical EngineeringConference PaperSCOPUS10.1109/NANO58406.2023.102312502-s2.0-8517358968019449380