Rujipat SamransamruajkitKawiwan LimprayoonRojanee LertbunrianRattapon UppalaChutima SamathakaneePravit JetanachaiNopparat ThamsiriChulalongkorn UniversityVajira HospitalKhon Kaen UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityFaculty of Medicine, Siriraj Hospital, Mahidol UniversityQueen Sirikit National Institute of Child HealthHat Yai Hospital2019-08-232019-08-232018-12-01Indian Journal of Critical Care Medicine. Vol.22, No.12 (2018), 846-8511998359X097252292-s2.0-85058885422https://repository.li.mahidol.ac.th/handle/123456789/46169© 2018 Medknow Publications. All rights reserved. Background: Sepsis is a common condition affecting the lives of infants and children worldwide. Although implementation of the surviving sepsis campaign (SSC) care bundles was once believed to be effective in reducing sepsis mortality rates, the approach has recently been questioned. Methods: The study was a prospective, interventional, multicenter trial. Infants and children aged 1 month to 15 years in seven different large academic centers in Thailand who had been diagnosed with severe sepsis or septic shock. They were given treatment based on the SSC care bundles. Results: A total of 519 children with severe sepsis or septic shock were enrolled in the study. Among these, 188 were assigned to the intervention group and 331 were recruited to the historical case-control group. There were no significant differences in the baseline clinical characteristics. The intervention group was administered a significantly higher fluid bolus than was the control group (28.3 ± 17.2 cc/kg vs. 17.7 ± 10.6 cc/kg; P = 0.02) with early vasopressor used (1.5 ± 0.7 h) compared to control group (7.4 ± 2.4 h, P < 0.05). More importantly, our sepsis mortality reduced significantly from 37% ± 20.7% during the preintervention period to 19.4% ± 14.3% during the postintervention period (P < 0.001). Conclusion: Our study demonstrated a significant reduction in sepsis mortality after the implementation of the SSC care bundles. Early diagnosis of the disease, optimum hemodynamic resuscitation, and timely antibiotic administration are the key elements of sepsis management.Mahidol UniversityMedicineArticleSCOPUS10.4103/ijccm.IJCCM_367_18