May HoH. Kyle WebsterMahidol UniversityArmed Forces Research Institute of Medical Sciences, Thailand2018-06-142018-06-141990-01-01Immunology Letters. Vol.25, No.1-3 (1990), 135-138016524782-s2.0-0025150827https://repository.li.mahidol.ac.th/handle/20.500.14594/15968T lymphocyte responses to malaria-specific antigens during acute falciparum malaria were studied to determine host-parasite interaction and its relation to the manifestations of the disease. The results indicate that while there is antigen-specific immunodepression, markedly elevated levels of soluble factors such as IL 2 receptor, CD8 antigen and IFN-γ suggest that there is intense concurrent cellular activation which however does not seem to be effective in controlling the infection. It is proposed that the cellular activation is to a large extent non-specific and polyclonal, and leads to the exaggerated production of cytokines and eventually immunopathology. Various mechanisms of immunodepression are discussed. © 1990.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1016/0165-2478(90)90104-X