Chainarong PhalanusitthephaHaruhiro InoueHaruo IkedaHiroki SatoChiaki SatoChananya HokiertiMahidol UniversityShowa University2018-11-092018-11-092014-03-01Annals of Translational Medicine. Vol.2, No.3 (2014)23055847230558392-s2.0-85015488890https://repository.li.mahidol.ac.th/handle/20.500.14594/34278© Annals of Translational Medicine. All rights reserved. Peroral endoscopic myotomy (POEM) is one of the alternative treatment for achalasia. Due to concept of natural orifice transluminal endoscopic surgery (NOTES), it becomes popular and widely accepted. With the endoluminal technique, submucosal tunnel was created followed by endoscopic myotomy. POEM is not only indicated in classical achalasia but also other abnormal esophageal motility disorders. Moreover, failures of endoscopic treatment or surgical attempted cases are not contraindicated for POEM. The second attempted POEM is also safe and technically feasible. Even though the legend of success of POEM is fruitful, the possible complications are very frightened. Good training and delicate practice will reduce rate of complications. This review provides a summary of current state-of-the-art of POEM, including indication equipments, technique and complications. This perfect procedure may become the treatment of choice of achalasia and some esophageal motility disorders in the near future.Mahidol UniversityMedicineReviewSCOPUS10.3978/j.issn.2305-5839.2014.02.04