Hisaki NagaiMathurose PonglikitmongkolYong Sung KimKenichi MatsubaraHiroaki TsumuraMathurose PonglikitmongkolYong Sung KimOsaka UniversityHiroshima University Faculty of MedicineMahidol UniversityGenetic Engineering Research Institute2018-07-042018-07-041995-10-15Cancer Research. Vol.55, No.20 (1995), 4549-455115387445000854722-s2.0-0028875208https://repository.li.mahidol.ac.th/handle/123456789/17237Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et aL, Proc. Natl. Acad. Sci. USA, 88:9523–9527, 1991). About 2000 Notl restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor. © 1995, American Association for Cancer Research. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS