S. IntahphuakA. PanthongD. KanjanapothiT. TaesotikulC. KrachangchaengV. ReutrakulChiang Mai UniversityMahidol University2018-07-242018-07-242004-01-01Journal of Ethnopharmacology. Vol.90, No.1 (2004), 69-72037887412-s2.0-0345862085https://repository.li.mahidol.ac.th/handle/20.500.14594/21813The chloroform extract from the roots of Mallotus spodocarpus was investigated for anti-inflammatory and analgesic activities in animal models. In acute inflammatory models, the extract significantly inhibited ethyl phenylpropiolate-induced ear edema and carrageenin- and arachidonic acid-induced hind paw edema in rats. In the chronic inflammatory model using the cotton pellet-induced granuloma in rats, the extract exhibited inhibitory activity on the formation of granuloma. The extract also elicited pronounced inhibitory effect on acetic acid-induced writhing response in mice in the analgesic test. The results obtained suggest marked anti-inflammatory and analgesic activity of the extract. © 2003 Elsevier Ireland Ltd. All rights reserved.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.jep.2003.09.026