Malaria GenAmbroise AhouidiMozam AliJacob Almagro-GarciaAlfred Amambua-NgwaChanaki AmaratungaRoberto AmatoLucas Amenga-EtegoBen AndagaluTim J.C. AndersonVoahangy AndrianaranjakaTobias ApinjohCristina ArianiElizabeth A. AshleySarah AuburnGordon A. AwandareHampate BaVito BarakaAlyssa E. BarryPhilip BejonGwladys I. BertinMaciej F. BoniSteffen BorrmannTeun BousemaOralee BranchPeter C. BullGeorge B.J. BusbyThanat ChookajornKesinee ChotivanichAntoine ClaessensDavid ConwayAlister CraigUmberto D'AlessandroSouleymane DamaNicholas PJ DayBrigitte DenisMahamadou DiakiteAbdoulaye DjimdéChristiane DolecekArjen M. DondorpChris DrakeleyEleanor DruryPatrick DuffyDiego F. EcheverryThomas G. EgwangBerhanu ErkoRick M. FairhurstAbdul FaizCaterina A. FanelloMark M. FukudaDionicia GamboaAnita GhansahLemu GolassaSonia GoncalvesWilliam L. HamiltonG. L.Abby HarrisonLee HartChrista HenrichsTran Tinh HienCatherine A. HillAbraham HodgsonChristina HubbartMallika ImwongDeus S. IshengomaScott A. JacksonChris G. JacobBen JefferyAnna E. JeffreysKimberly J. JohnsonDushyanth JyothiClaire KamaliddinEdwin KamauMihir KekreKrzysztof KluczynskiTheerarat KochakarnAbibatou KonatéDominic P. KwiatkowskiMyat Phone KyawPharath LimChanthap LonKovana M. LouaOumou Maïga-AscofaréCinzia MalangoneMagnus ManskeJutta MarfurtKevin MarshMayfong MayxayAlistair MilesOlivo MiottoVictor MobegiOlugbenga A. MokuoluJacqui MontgomeryIvo MuellerPaul N. NewtonThuy NguyenThuy Nhien NguyenHarald NoedlFrançois NostenRintis NoviyantiAlexis NzilaMahidol Oxford Tropical Medicine Research UnitOxford University Clinical Research UnitCSIR - Institute for Scientific and Technological InformationUniversité de MontpellierInstituto de Salud Global de BarcelonaUniversidad IcesiThe Wellcome Centre for Human GeneticsMinistry of Health LaosMalawi-Liverpool-Wellcome Trust Clinical Research ProgrammeUniversité d'AntananarivoUniversity of CocodyNavrongo Health Research CenterMinistry of Health GhanaKwame Nkrumah University of Science and TechnologyNational Institute for Medical Research TangaUniversite Cheikh Anta DiopUniversidad Peruana Cayetano HerediaAddis Ababa UniversityUniversity of BueaAfrican Academy of SciencesKenya Medical Research InstituteEijkman Institute for Molecular BiologyUniversity of Nairobi Medical SchoolWellcome Trust Research Laboratories NairobiCentro Internacional de Entrenamiento e Investigaciones MedicasShoklo Malaria Research UnitLondon School of Hygiene & Tropical MedicineUniversity of CambridgeUniversity of GeorgiaIRD Institut de Recherche pour le DeveloppementWalter and Eliza Hall Institute of Medical ResearchUniversity of OxfordMenzies School of Health ResearchNYU Grossman School of MedicineTexas Biomedical Research InstituteLiverpool School of Tropical MedicineBernhard Nocht Institut fur Tropenmedizin HamburgMonash UniversityDeakin UniversityUniversity of GhanaNational Institute of Allergy and Infectious Diseases (NIAID)Eberhard Karls Universität TübingenCambridge University Hospitals NHS Foundation TrustArmed Forces Research Institute of Medical Sciences, ThailandMahosot Hospital, LaoUniversiteit AntwerpenWalter Reed Army Institute of ResearchMahidol UniversityUniversity of IlorinKing Fahd University of Petroleum and MineralsPurdue UniversityNuffield Department of MedicineNational Institutes of Health (NIH)Wellcome Sanger InstituteBurnet InstituteRadboud University Medical CenterMedical Care Development InternationalMalaria Research Initiative Bandarban (MARIB)Institut National de Santé PubliqueEast African Consortium for Clinical Research (EACCR)Biotech LaboratoriesInstitut National de Recherches en Santé PubliqueUniversity of SciencesDev Care FoundationUniversity of Public Health2022-08-042022-08-042021-01-01Wellcome Open Research. Vol.6, (2021), 1-312398502X2-s2.0-85113375527https://repository.li.mahidol.ac.th/handle/20.500.14594/76344MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.12688/wellcomeopenres.16168.2