Kanchana SujirachatoPimol ChiewsilpTasanee MongkolsukSureeporn JunpongVasant SumethkulSopon JirasirithamSuthus SriphojanartSiroj KanjanapanjapolSomnuek DomrongkitchaipornMahidol University2018-07-042018-07-041997-09-01Journal of the Medical Association of Thailand. Vol.80, No.SUPPL. 1 (1997)012522082-s2.0-2442555258https://repository.li.mahidol.ac.th/handle/20.500.14594/18082Two hundred and fifty-three kidney transplantations (KT) which included 68 (26.9%) living-related (L) and 185 (73.1%) cadaveric (C) KT with 0-6 KDLA-ABDR mismatches (MM) were studied for the association of HLA-ABDR-MM specificities and the occurrence of graft rejection (GR). It was found that the incidence of acute and chronic rejection in CKT was significantly higher than that of LKT (42.1% vs 22.1%, p<0.005). It was also observed that the number of ABDR-MM, AB-MM and BDR-MM which is important in GR were 2 times in CKT compared with LKT. The analysis revealed that HLA-A11, B16, B22, B35, B5, B17 and DR3 were good responders, whereas, HLA-A30, A2, B62, B18, B40, B44, B46 and DR10 were good stimulators for KT. GR were significantly increased with p<0.01 and <0.05, respectively. Specific HLA-MM specificities played a significant role in GR, i.e., some HLA-MM specificities were permissible, whereas, some were immunogenic. Careful selection of donor and recipient for KT by avoiding immunogenic HLA-MM and/or accepting permissible HLA-MM will improve graft survival and reduce the demand of kidney for retransplantation.Mahidol UniversityMedicineArticleSCOPUS