P. Tan-AriyaC. R. BrockelmanC. MenabandhuMahidol University2018-10-122018-10-121984-12-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.15, No.4 (1984), 531-535003836192-s2.0-0021591129https://repository.li.mahidol.ac.th/handle/20.500.14594/30627The efficacy of mefloquine against Plasmodium falciparum in continuous culture was studied. The development of mefloquine resistance in P. falciparum was significantly inhibited by a combination of mefloquine, pyrimethamine and sulfadoxine. By contrast, more resistant variants were selected in continuous culture without drug pressure or with pyrimethamine-sulfadoxine pressure. The most mefloquine resistant variants were selected by step-wise increases in mefloquine pressure.Mahidol UniversityMedicineArticleSCOPUS