Hou K.Börgel J.Jiang H.Z.H.SantaLucia D.J.Kwon H.Zhuang H.Chakarawet K.Rohde R.C.Taylor J.W.Dun C.Paley M.V.Turkiewicz A.B.Park J.G.Mao H.Zhu Z.Ercan Alp E.Zhao J.Hu M.Y.Lavina B.Peredkov S.Lv X.Oktawiec J.Meihaus K.R.Pantazis D.A.Vandone M.Colombo V.Bill E.Urban J.J.David Britt R.Grandjean F.Long G.J.DeBeer S.Neese F.Reimer J.A.Long J.R.Mahidol University2023-12-112023-12-112023-11-01Science Vol.382 No.6670 (2023) , 547-55300368075https://repository.li.mahidol.ac.th/handle/20.500.14594/91429In nature, nonheme iron enzymes use dioxygen to generate high-spin iron(IV)=O species for a variety of oxygenation reactions. Although synthetic chemists have long sought to mimic this reactivity, the enzyme-like activation of O2 to form high-spin iron(IV) = O species remains an unrealized goal. Here, we report a metal–organic framework featuring iron(II) sites with a local structure similar to that in a-ketoglutarate-dependent dioxygenases. The framework reacts with O2 at low temperatures to form high-spin iron(IV) = O species that are characterized using in situ diffuse reflectance infrared Fourier transform, in situ and variable-field Mössbauer, Fe Kb x-ray emission, and nuclear resonance vibrational spectroscopies. In the presence of O2, the framework is competent for catalytic oxygenation of cyclohexane and the stoichiometric conversion of ethane to ethanol.MultidisciplinaryArticleSCOPUS10.1126/science.add74172-s2.0-851763750581095920337917685