Karunee KwanbunjanPhimonsri SaengkarCheeraratana CheeramakaraWanyarat ThanomsakWanpen BenjachaiPikul LaisupasinKasinee BuchachartKriyaporn SongmuaengNaiyana BoontaveeyuwatMahidol UniversityNational Cancer Institute ThailandChonburi Cancer Hospital2018-06-212018-06-212005-07-01Nutrition Research. Vol.25, No.7 (2005), 641-654027153172-s2.0-24344469140https://repository.li.mahidol.ac.th/handle/123456789/16325The relationship between folate status and the risk of cervical dysplasia was studied among Thai women. The subjects were composed of 44 women with low-grade cervical neoplasia (cervical intraepithelial neoplasm I), 70 women with high-grade cervical neoplasia (cervical intraepithelial neoplasm II, III, and carcinoma in situ), and 95 women who served as controls. The low folate status in these women showed a strong association with cervical dysplasia. Serum folate was markedly lower in both low-grade (P < .01) and high-grade cervical neoplasia cases (P < .01) compared with the control women. Using logistic regression, the odds ratio for low-grade cervical neoplasia with low serum folate level (<19.82 nmol/L) was 6.13, whereas that of the high-grade group with the same folate level was 5.57. The findings support the contention that folate deficiency of women in this study had an increased risk of cervical change. © 2005 Elsevier Inc. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/j.nutres.2005.05.004